منابع مشابه
Bordetella pertussis and pertussis vaccines.
Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the a...
متن کاملEpidemiological evidence for herd immunity induced by acellular pertussis vaccines.
In a series of elegant experiments on baboons, Warfel et al. conclude that acellular pertussis vaccines (aP) prevent disease but fail to protect against transmissible infection (1). The authors speculate that this fact may explain the resurgence of pertussis in some countries (2). Although the animal model of Warfel et al. is a true breakthrough, we question the soundness of their extrapolation...
متن کاملPertussis Vaccines
s of references provided in the position paper and GRADE tables Amirthalingam G, Andrews N, Campbell H, Ribeiro S, Kara E, Donegan K, et al. Effectiveness of maternal pertussis vaccination in England: an observational study. Lancet 2014 Oct 25; 384(9953):1521-1528. BACKGROUND: In October, 2012, a pertussis vaccination programme for pregnant women was introduced in response to an outbreak acro...
متن کاملBordetella pertussis polymorphism and pertussis vaccines.
The topic of the article by Bottero et al. (1) is an important one, a bacterial vaccine for a preventable disease, pertussis. Many articles have been published on the subject in the last 10 years (for a review, see reference 6). In their study, Bottero et al. neither followed the recommendations of consensus meetings nor used published nomenclature. Furthermore, they compared vaccines that cann...
متن کاملProtective Immunity in Mice Following Immunization with the Cochleate-Based Subunit Influenza Vaccines
High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2019
ISSN: 0952-7915
DOI: 10.1016/j.coi.2019.03.006